Corneal endothelial changes in patients wearing soft contact lens

Mustafa DURAN, Volkan YETER, Osman SAYIN, Hakkı BİRİNCİ, İnci GÜNGÖR
2.089 554

Abstract


We aimed to compare the cornea thickness and corneal endothelial parameters of young myopic individuals regularly wearing soft silicon hydrogel contact lens for at least one year with those of control group. Central cornea thickness was determined with Galilei Dual-Scheimplug Analyzer by performing anterior segment scanning to the both eyes of young myopic individuals wearing soft contact lens regularly for more than one year and those never worn contact lens before (control group). Full thickness corneal scanning was performed using confocal microscope after administration of topical anesthesia. Endothelial count, polymegathism and pleomorphism values were determined via automatic endothelial analysis. Mann Whitney-U test was used for comparison of the groups. Of the 16 individuals wearing contact lens, 3 were male, 13 were female. The mean contact lens wearing time was 3.5 years (between 1 and 8 years). Of the 26 individuals in the control group, 8 were female, 18 were male. No statistically significant difference was observed between contact lens wearing and control groups in terms of age, refraction, central corneal thickness, pleomorphism and endothelial cell count whereas polymegathism was the only significant parameter between groups (p=0.021). Endothelial polymegathism was more common in individuals wearing silicon hydrogel soft contact lens than those in control group. The use of silicon hydrogel soft contact lens may cause alterations in corneal endothelial cell structure in the long period.

J. Exp. Clin. Med., 2013; 30:27-29

Keywords


Contact lens; endothelial cell; polymegathism; pleomorphism

Full Text:

27-29


DOI: http://dx.doi.org/10.5835/jecm.omu.30.01.007

References


Barr, T.J., 2005. History and development of contact lenses. In: Bennet, S.E.,Weissman, A.B. Clinical contact lens practice. Lippincott Williams &Wilkins. Section 1, chapter 1, 1-10.

Bourne, W.M., Nelson L.R., Hodge, D.O., 1997. Central corneal endothelial cell changes over a ten- year period. Invest. Ophtalmol. Vsi. Sci. 38, 779-782.

Bourne, W.M., 2001. The effect of long-term contact lens wear on the cells of the cornea. Clao J. 27, 225-230.

Doughty, M.J., Aakre, B.M., Ystenaes, A.E., Svarverud, E., 2005. Short-term adaptation of the human corneal endothelium to continuous wear of silicone hydrogel (lotrafilcon A) contact lenses after daily hydrogel lens wear. Optom. Vis. Sci. 82, 473-480.

Hofstetter, H.W., Graham, R., 1953. Leonardo and contact lenses. Am J Optom Arch Am Acad Optom. 30, 41-44.

Holden, B.A., Sweeney, D.F., Vannas, A., Nilsson, K.T., Efron, N., 1985. Effects of long-term extended contact lens wear on the human cornea. Invest. Ophtalmol. Vis. Sci. 26, 1489-1501.

Lee, S.Y., Kim, Y.H., Johnson, D., Mondino, B.J., Weismann, B.A., 2012. Contact lens complications in an urgent-care population: The University of California, Los Angeles, contact lens study. Eye Contact Lens. 38, 49-52.

Lee, J.S., Park, W.S., Lee, S.H., Oum, B.S., Cho, B.M., 2001. A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear. Graefes Arch. Clin. Exp. Ophthalmol. 239, 1-4.

Leem, H.S., Lee, K.J., Shin, K.C., 2011. Central corneal thickness and corneal endothelial cell changes caused by contact lens use in diabetic patients. Yonsei Med. J. 52, 322-325.

Leung, B.K., Bonanno, J.A., Radke, C.J., 2011. Oxygen-deficient metabolism and corneal edema. Prog. Retin. Eye Res. Nov. 30, 471-492. Phillips, C., Laing, R., Vee, R., 2005. Specular microscopy. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. 2nd ed. Vol 1. Philadelphia: Elsevier/Mosby: 261-281.

Rao, G.N., Shaw, E.L., Arthur, E.J., Aquavella, J.V., 1979. Endothelial cell morphology and corneal de turgescence. Ann. Ophthalmol. 11, 8858

Schoessler, J.P., Woloschak, M.J., Mauger, T.F., 1982. Transient endothelial changes produced by hydrophilic contact lenses. Am. J.Optom. Physiol. Opt. 59, 764-765.

Sheng, H., Bullimore, M.A., 2007. Factor affecting corneal endothelial morphology. Cornea Jun. 26, 520-525.

Sibug, M.E., Datiles, M.B. 3rd., Kashima, K., McCain, L., Kracher, G., 1991. Specular microscopy studies on the corneal endothelium after cessation of contact lens wear. Cornea. 10, 395-401.

Yee, R.W., Matsuda, M., Schultz, R.O., Edelhauser, H.F., 1985. Changes in the normal corneal endothelial cellular pattern as a function of age. Curr. Eye Res. 4, 671-678.

Zantos, S.G., Holden, B.A., 1977. Transient endothelial changes soon after wearing soft contact lenses. Am. J. Optom. Phsiol.Opt. 54, 8568