Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Elfide Gizem KIVRAK, Işınsu AYDIN, Gamze TÜMENTEMUR, B. Zuhal ALTUNKAYNAK, Süleyman KAPLAN
1.819 972

Abstract


Obesity, a condition that is characterized by the excessive accumulation and storage of body fat, is one of the most significant and common diseases of today’s world and it is
measured by a method called body mass index (BMI). Obesity can result in many serious diseases such as, hypertension, diabetes, cardiovascular diseases and hyperlipidemia.
Non-alcoholic fatty liver disease is one cause of a fatty liver that occurs when fat is deposited in the liver not due to the excessive alcohol use. Histopathological findings of fatty liver are seen in hepatocytes within the forms of micro-vesicular and macrovesicular steatosis or sometimes housing fat vacuoles. Leptin, one of the most important adipose-derived hormones and among the best-known hormone markers for obesity plays a key role in regulating stable body weight and is synthesized and released by the fat cells in adipose tissue. The aim of this study was to detect the effects of high fat diet induced obesity and leptin on liver by using physical disector and Cavalieri methods.

Keywords


High fat diet Leptin; Non-alcoholic fatty liver disease; Obesity Rat

Full Text:

141-145


DOI: http://dx.doi.org/10.5835/jecm.omu.30.02.011

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